If you would like to gain a clearer and more comprehensive understanding of the management of cosmetic ingredients in China, we invite you to explore our previous article, Cosmetic Ingredients in China: Your Guide to the Latest Compliance Requirements. It provides helpful insights to build a solid foundation before diving into this topic.
From April 22 to 28, 2025, 7 new cosmetic ingredients were notified with the China National Medical Products Administration (NMPA). They include:
The technical requirements for the 7 new cosmetic ingredients mentioned above have not been disclosed, and they have not yet entered the safety monitoring period.
Among the seven newly notified NCIs, three are peptide-based. Of these, two ingredients—Tripeptide-29 and Acetyl Hexapeptide-95 Amide—were notified by Winkey Technology. According to available data, Winkey has so far completed the notifications of 15 NCIs involving 13 different ingredients, ranking first among companies in terms of the number of notifications.
In recent years, the rise of "Chinese ingredients" has driven rapid growth across the cosmetic raw material sector. Winkey Technology, founded in 2011, is among the companies that have developed alongside this trend. Initially applying peptide drug development technologies to the cosmetic field, Winkey has focused on the research and development of innovative peptide ingredients. Over the past 14 years, it has expanded its product offerings to include a series featuring Chinese characteristic ingredients, synthetic biology-derived actives, and sensory raw materials.
Related Report:
Unlocking Opportunities in China's Booming Peptide Market: Key Insights and Compliance Pathways
Chrysanthemum Lavandulifolium Extract
Chrysanthemum Lavandulifolium, which is called “神农香菊” in Chinese, is a perennial herbaceous plant of the Asteraceae family, native to the Shennongjia Forestry District, in northwestern Hubei province. On July 17, 2016, Hubei Shennongjia was listed as a World Heritage Site, the 50th World Heritage Site in China, because of its exceptional floral and faunal biodiversity and its protection of many rare, endangered, and endemic species.
Known for its strong aromatic fragrance, Chrysanthemum Lavandulifolium is rich in terpenes such as α-cedrol and β-cedrol, as well as flavonoids. Locals often use its dried flowers and leaves to make fragrant sachets or as medicinal herbs for their cooling, anti-inflammatory properties. It holds significant pharmacological value.
Pyrus Ussuriensis Fruit Powder
Pyrus Ussuriensis is a species under the Rosaceae family, specifically the genus Pyrus. It is native to the Ussuri River basin and is known for its strong cold resistance, thriving in cold, dry mountain regions at altitudes of 100-2000 meters. The tree is widely cultivated in Northeast China, North China, and Northwest China, with many varieties. Autumn Pear is traditionally used in Chinese medicine for its effectiveness in clearing the lungs and relieving coughs, often combined with rock candy syrup.
This NCI notification(20250043) marks the fourth public announcement for the notification of Fucosyllactose and the fifth notification for human milk oligosaccharides (HMOs).
In the cosmetics industry, Fucosyllactose has been included in the EU CosIng database and the US PCPC ingredient directory, primarily serving as a skin conditioning agent and skin protectant.
In the food industry, 2'-Fucosyllactose (2'-FL) has been approved for use in foods across multiple countries and regions, including the United States, the EU, Australia, and New Zealand. In China, 2'-FL has been reviewed and approved by the National Health Commission for use as a food nutritional enhancer.
The notifier, Shandong Henglu Biotechnology Co., Ltd, has successfully developed a unique "enzyme/yeast dual-method" technology through independent innovation. By using carbohydrates as substrates and employing both domestic and international advanced processes, the company has successfully synthesized various human milk oligosaccharides (HMOs), including LNB, LNT, LNnT, LNT II, and 2'-FL.
