If you would like to gain a clearer and more comprehensive understanding of the management of cosmetic ingredients in China, we invite you to explore our previous article — Cosmetic Ingredients in China: Your Guide to the Latest Compliance Requirements. It provides helpful insights to build a solid foundation before diving into this topic.
From April 29 to May 9, 2025, 5 new cosmetic ingredients were notified with the China National Medical Products Administration (NMPA). They include:
The technical requirements for the 5 new cosmetic ingredients mentioned above have not been disclosed, and they have not yet entered the safety monitoring period.
Notification No. 20250044
A peptide-based ingredient composed of 22 amino acids. The notifier, Zhejiang Peptites Biotech CO.,LTD, has conducted a series of studies demonstrating that the synthetic ingredient offers strong stability, low toxicity, and other favorable properties, highlighting its promising potential for future development.
Notification No. 20250046
A peptide ingredient tentatively referred to as Acetyl Octapeptide-6 (Chinese name: 乙酰基八肽-6), based on a direct translation following the naming convention of Acetyl Octapeptide-1. According to public records, the notifier’s parent company previously submitted Acetyl Octapeptide-1 in October 2023 (Notification No. 20230040). The ingredient was notified as a skin protectant and approved for use in a wide range of cosmetic products, excluding those intended for the lips, oral cavity, or spray applications.
For more information on the compliance of peptide-based ingredients, please refer to our previous articles.
Notification No. 20250045 marks the third time Vitamin K2 has been notified in China, each by a different domestic company.
According to the notifier, Maiggic, this submission concerns Vitamin K2 (MK-7), a subtype featuring seven isoprene units in its side chain. As a fat-soluble vitamin, it plays a vital role in human health. Natural sources include animal liver, meat, legumes, fermented dairy products, and especially natto, which contains the highest levels.
Globally, Vitamin K2 is widely used in dietary supplements, pharmaceuticals, medical foods, beverages, fermented yogurts, dairy products, cosmetics, and animal feed. Studies have shown its notable benefits in antioxidant activity, reducing inflammatory markers like TSLP and IL-8, enhancing mitochondrial function and ATP production, and helping improve the appearance of dark circles.
Notification No. 20250046 concerns an extract derived from various parts of Acanthopanax sessiliflorus, a deciduous shrub or small tree known for its dual use in both medicine and food. The plant is mainly distributed across China's northeastern and northern provinces, as well as in North Korea and the Russian Far East. In May 2008, China's Ministry of Health (now the National Health Commission) approved cultivated Acanthopanax sessiliflorus as a novel food, with its stems, leaves, and fruits permitted for use in beverages and alcoholic products.
Its recent notification as a new cosmetic ingredient highlights the growing interest in "food-cosmetic homologous" ingredients and marks its expanding role in the cosmetics sector.
Notification No. 20250047 pertains to diacylglycerol (DAG), a natural lipid derived from Camellia oleifera seed oil, which exists in two isomeric forms: 1,3-DAG and 1,2-DAG.
According to the EU CosIng database, glyceride-based ingredients are commonly used in cosmetics as surfactants, emulsifiers, and skin-conditioning agents.
Among the five NCIs in this issue, two were successfully notified with ZMUni's support. Our NCI team provided end-to-end guidance—from strategy design to documentation—tailored to each ingredient's characteristics, helping clients navigate key challenges and complete the notifications smoothly.
With over 30 successful NCI notifications and 100+ projects in progress, we bring extensive experience across various ingredient types and submission scenarios. If you have related notification needs or questions, feel free to reach out—we're here to help!
