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From April 13 to 17, 2026, 5 new cosmetic ingredients (NCIs) have completed notifications with China's National Medical Products Administration (NMPA).
According to public reports, this is a novel natural polypeptide preservative derived from marine antimicrobial peptides. It is unmodified, with a clear mechanism of action and no known risk of inducing antimicrobial resistance.
The ingredient provides effective antimicrobial protection alongside anti-inflammatory, antioxidant, and skin-repair benefits. It is stable under high temperatures and across a wide pH range, highly water-soluble, and non-irritating, making it suitable for sensitive skin applications. Produced via fermentation or synthesis, it can significantly reduce reliance on conventional preservatives and has been adopted by brands including Shiseido and Proya.
Ceramide EOS, a functional lipid ingredient notified by Zhihe Bio, is produced through a combination of bio-fermentation and green chemical synthesis. Through targeted structural modification, the molecule is optimized while retaining the classic benefits of ceramides in moisturizing and skin barrier repair. It also offers hair-conditioning properties, enabling dual applications in both skincare and haircare formulations.
This NCI was completed with the support of ZMUni Compliance Centre. By leveraging extensive experience with ceramide-type ingredients and full-chain regulatory expertise, ZMUni provided end-to-end support—from early-stage feasibility assessment and regulatory pathway alignment to dossier preparation—ensuring an efficient and compliant submission process.
Chimonanthus salicifolius, a species of the Calycanthaceae family, is endemic to China and is mainly distributed in regions such as Jiangxi Province. Extracts from its leaves and stems are rich in flavonoids—represented by kaempferol and its derivative kaempferol-3-O-rutinoside—as well as polymethoxylated coumarins.
These bioactive compounds have been shown to activate fibroblasts, promote the synthesis of type I procollagen and elastin, and inhibit excessive activity of matrix metalloproteinases (MMPs), thereby helping to reduce the degradation of collagen and elastic fibers.
Solanum betaceum, commonly known as tree tomato, is a shrub belonging to the Solanaceae family. Native to South America, it has been introduced to tropical and subtropical regions worldwide, with cultivation reported in China's Yunnan Province and southern Tibet.
Hydroxytyrosol is a phenylethanol derivative naturally found in olive oil and olive leaves from the olive tree. It exhibits both lipid and water solubility, along with strong antioxidant activity. According to CosIng, it is typically produced via organic synthesis and is classified as a skin conditioning and bleaching agent for cosmetic use.
To date, a total of six hydroxytyrosol ingredients have completed notification in China. Among them, three have entered the three-year safety monitoring period, indicating that they have already been applied in finished cosmetic products.
