From December 1 to 9, 2025, 4 new cosmetic ingredients (NCIs) were notified with the China National Medical Products Administration (NMPA).
The technical requirements for the 4 new cosmetic ingredients mentioned above have not been disclosed, and they have not yet entered the safety monitoring period. Notably, three out of the four NCIs are peptides.
This ingredient, notified by Winkey Technology, is a type of cyclic hexapeptide. Peptide ingredients among the currently notified NCIs have seen rapid growth over the past two years, but cyclic peptides are still quite limited. Including the NCIs notified this time, there are a total of four cyclic peptides, with Winkey alone accounting for two of them.
Founded in 2011, Winkey Technology focuses on the R&D, production, and sales of cosmetic ingredients. Its core expertise lies in bioactive skin peptides, complemented by Chinese plant-based ingredients and expanded through key general additives. Winkey Technology's major clients include international brands such as Procter & Gamble, Unilever, and Shiseido; international cosmetic manufacturers including Cosmax, Intercos, and Kolmar Korea; as well as well-known Chinese brands and emerging players such as Marubi, Dr. Ling, Fan Wenhua, OSM, HBN, and Proya.
3'-Sialyllactose sodium salt (3'-SL) is composed of N-acetylneuraminic acid (Neu5Ac, also known as sialic acid), galactose, and glucose. As a human milk oligosaccharides (HMOs), 3'-SL has been approved by authorities such as the US and EU for use in infant formula and other food categories. It can be added to infant milk powders as well as adult nutritional products.
The notifier, DSM-Firmenich Nutrition Products (Shanghai) Co., Ltd., is part of DSM-Firmenich—a Swiss-Dutch group focused on nutrition, health, and personal care. In October 2025, the company notified another HMO-related NCI, Lacto-N-neotetraose (Notification 20250133).
To date, a total of nine HMO-related NCIs have been notified. The details are as follows:
Bicyclic Octapeptide-66 is a bicyclic peptide. PCPC has listed its functions as an antioxidant and skin-protecting agent. To date, a total of 50 peptide-based NCIs have been notified, accounting for 13.9% of all NCI notifications. Of these, 14 ingredients have already entered the safety monitoring period.
