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China's NCI Approval Updates: Expanding Botanical Pipeline and Growing Functional Anti-Aging Actives
Published on:2026-04-30

 

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From April 20 to 29, 2026, 8 new cosmetic ingredients (NCIs) have completed notifications with China's National Medical Products Administration (NMPA).

 

 

Botanical Extracts

 

Nitraria tangutorum is a species in the genus Nitraria (family Nitrariaceae), typically found in desert and semi-desert regions. Its fruits are rich in proteins, amino acids, polysaccharides, and various trace elements.

 

Solanum americanum is an annual herb in the genus Solanum (family Solanaceae). Native to tropical regions of the Americas, it is now widely distributed across tropical and subtropical regions worldwide. It has been traditionally associated with properties such as heat-clearing, detoxification, and reducing swelling.

 

Trillium tschonoskii (a perennial herb of the genus Trillium, family Melanthiaceae) is a medicinal plant with a long history of use in China. Its rhizome extract is rich in steroidal saponins and other bioactive constituents, and is associated with anti-inflammatory, soothing, and antioxidant stress–modulating activities, making it a representative traditional medicinal plant with dual food and medicinal use potential.

  

 

Specialty Plant Oils

 

Acer truncatum is a deciduous tree species of the genus Acer in the Sapindaceae family. It is widely distributed in China.

 

Acer truncatum seed oil, sometimes referred to as “natural brain gold,” was officially approved in March 2011 by the former Ministry of Health of China (now the National Health Commission) as a novel food ingredient. The oil is produced from the kernels of Acer truncatum seeds through pressing, decolorization, and deodorization processes.

 

 

Anti-Aging Ingredients

 

NMN (nicotinamide mononucleotide) is a precursor of NAD⁺, a key coenzyme involved in cellular energy metabolism. It has been widely studied for its potential role in supporting cellular energy production, DNA repair processes, and anti-aging mechanisms. In the context of China's NCI regulatory framework, NMN has become one of the most frequently notified NCIs. To date, a total of 14 NMN-related notifications have been filed, including 4 that have since been withdrawn.

 

Fisetin is a naturally occurring flavonol found in various fruits and vegetables, including strawberries, apples, persimmons, lotus roots, and onions. As a member of the polyphenol family, it exhibits well-documented bioactivities, particularly antioxidant and anti-inflammatory properties.

  

 

Fermented/Biotech Products

 

Ganoderma lucidum spore fermented oil is a cosmetic ingredient developed through a biofermentation-based synthetic biology approach. According to patent disclosures, it is produced via engineered yeast combined with Lactobacillus co-fermentation.

 

The approach reflects a broader industry shift toward using microbial fermentation platforms to rework traditional botanical actives, aiming to improve both the bioavailability of triterpenoids from Ganoderma lucidum spores and their sensory profile, particularly reducing greasiness.

 

The ingredient is positioned for multifunctional cosmetic applications such as skin brightening, anti-aging, and skin repair, aligning with the growing demand for biotech-derived and multifunctional actives.

 

 

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