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China's NCI Approval Updates: Peptides, Botanicals & Functional Molecules
Published on:2026-06-15

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From June 8 to June 12, 2026, 7 new cosmetic ingredients (NCIs) have completed notifications with China's National Medical Products Administration (NMPA).

 

 

Peptides

 

Notification No. 20260097 - sr-(Tripeptide-133 sh-Polypeptide-2 Hexapeptide-40)

 

According to the publicly available patent filed by the notifier (CN120918980A), sr-(Tripeptide-133 sh-Polypeptide-2 Hexapeptide-40) demonstrates strong antioxidant activity and can act synergistically with other active ingredients. It enables the development of a new, high-performance active ingredient system applicable in both skincare and hair care products, enhancing antioxidant and repair-related efficacy.

 

 

Notification No. 20260100

 

Hexapeptide-125 (translated from Chinese name, official INCI name currently unavailable) was notified by Deqing Osmun Biological Co., Ltd., a subsidiary of OSM Group Co., Ltd. OSM is a Chinese full-value-chain cosmetics company founded in 1967, with core expertise in pearl deep processing and pearl-derived peptide technologies.

 

 

Notification No. 20260101 - Cyclo Hexapeptide-120

 

Cyclo Hexapeptide-120 is a synthetic cyclic peptide composed of six amino acids linked end-to-end to form a ring structure. In cosmetic applications, it is registered for use as a skin-conditioning agent and hair conditioning agent.

 

 

 

Botanicals

 

Notification No. 20260098 - Penthorum Chinense Leaf/Stem Extract

 

Penthorum chinense is a traditional medicinal herb that grows at altitudes ranging from 90 to 2,200 meters in forested areas, shrub meadows, and near water sources. It is distributed across eastern and southwestern China, as well as the Russian Far East, Japan, and Korea. The whole plant is used in traditional medicine and is considered to have sweet and warm properties, traditionally associated with promoting diuresis, eliminating dampness, relieving pain, and addressing conditions such as jaundice, edema, and bruising. Its young shoots are also edible.

 

 

Notification No. 20260099 - Dendrobium devonianum Stem Extract

 

Dendrobium devonianum is an epiphytic herb belonging to the Orchidaceae family and the Dendrobium genus. It is a nationally protected Class II wild plant in China. Its distribution includes Yunnan, Guangxi, Guizhou, and southeastern Tibet, as well as Thailand, Laos, and Vietnam.

 

The history of Yunnan Baiyao Group Co., Ltd. dates back to 1971, and the company was listed in 1993. Rooted in traditional Chinese medicine principles, it focuses on developing products that better meet the needs of modern lifestyles, enabling traditional medicine to be integrated into daily life in a more practical form. Its core product portfolio includes the Yunnan Baiyao aerosol, capsules, ointment, and toothpaste, all of which are widely recognized consumer health products in China.

 

 

 

Biotech & Functional Molecules

 

Notification No. 20260102 - Lacto-N-Neotetraose, LNnT

 

Lacto-N-neotetraose (LNnT) is an important member of the Human Milk Oligosaccharides (HMOs) family. Its molecular structure consists of galactose, glucose, and N-acetylglucosamine linked in a specific glycosidic pattern, forming a naturally highly polar, multi-hydroxyl structure. It delivers multiple functions, including hydration, skin protection, and hair conditioning, while demonstrating high safety suitability for sensitive skin types.

 

The notifier, Long Health Bio, has confirmed through in vitro efficacy studies and laboratory data that LNnT is intended for use as a skin protectant, humectant, and hair conditioning agent in cosmetic applications.

 

This NCI notification was supported by ZMUni Compliance Center. Leveraging experience in HMO-related cases, our team provided regulatory pathway assessment and dossier support, enabling efficient compliance approval of this high-value ingredient.

 

Notification No. 20260103 -Maleated Soybean Oil Glyceryl / Octyldodecanol Esters

 

Maleated Soybean Oil Glyceryl / Octyldodecanol Esters were notified by Ashland Inc. According to Ashland’s official website, the product is marketed under the trade name Antaron™ Soja Glyceride.

 

This ingredient is a biodegradable, water-resistant film-forming agent that provides water resistance and SPF enhancement in sunscreen and makeup formulations. It is suitable for use in sunscreens, lotions, gels, and color cosmetics, and demonstrates good compatibility with both organic and inorganic ingredients.

 

The ingredient was first notified by Ashland Inc. in May 2024. In May 2026, the notification was voluntarily withdrawn, and it was subsequently re-submitted in June 2026.

 

 

 

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