On October 30, 2025, the China National Medical Products Administration (NMPA) approved two new registered cosmetic ingredients: one whitening agent and one colorant. These are the second and third ingredients approved under China's CSAR, following Beiersdorf's Thiamidol630 in November 2024.
Dimethoxytolyl propylresorcinol (registration number: "国妆原注字20250002), was registered by Unigen Inc. Founded in 1996 and headquartered in Washington State, USA, Unigen Inc. is a company specializing in the research, development, and manufacture of natural active ingredients, with applications in dietary supplements, prescription drugs, and personal care products.
As announced by China NMPA, Dimethoxytolyl propylresorcinol has been registered as a whitening agent. Following safety and efficacy evaluation, it can be used in creams, lotions, gels, masks, and other skincare products, excluding products with potential inhalation exposure.
According to public sources, Dimethoxytolyl propylresorcinol(Trade Name: Nivitol®) is derived from a novel plant extract, Dianella ensifolia. The ingredient contains tyrosinase inhibitor blockers, which can reduce skin pigmentation. Clinical studies have shown its efficacy to be 20 times higher than leading whitening agents such as hydroquinone and kojic acid. It is reported that this ingredient is an Estée Lauder proprietary patented compound, currently used in Clinique products.
Anse® Luoshen Zhu (registration number: 国妆原注字20250003), registered by Beijing Shangjie Youlan Technology Co., Ltd., is the world's first high-molecular-weight colorant approved for cosmetic use.
Anse® Luoshen Zhu is developed using cutting-edge fourth-generation aqueous polyurethane synthesis technology. By covalently embedding chromophore groups into the polymer backbone, it forms a stable structure with a molecular weight far exceeding the skin penetration threshold, fundamentally overcoming the safety limitations of traditional colorants and establishing a novel "non-transdermal coloring" technology path.
Earlier this month, Anse® Luoshen Zhu was included in first batch of new cosmetic ingreidents (NCIs) for innovation guidance published by the National Institutes for Food and Drug Control (NIFDC), which features 16 innovative ingredient varieties.
Over the past years, Chinese regulatory authorities have issued policies to promote cosmetic industry development, focusing on innovation and safety. The approval of these two ingredients underscores that safety remains the top priority in ingredient evaluation, providing clear guidance for future registrations and highlighting a regulatory environment that supports both innovation and consumer protection.
https://www.nmpa.gov.cn/yaowen/ypjgyw/hzhpyw/20251031122735151.html?type=pc&m=
